Corresponding Address
Education
Teaching Experience || Fellowships Obtained
Educational Affiliation || Award Obtained
Principal Investigator of Research Projects
Scientific Publications and Communication
Scientific Presentations
Corresponding Address
Prof. Haseena Khan
Department of Biochemistry and Molecular Biology
University of Dhaka
Dhaka 1000
Bangladesh
Telephone number 880-2-9661900-49 Ext. 6102 (work)
880-2-8917159 ( home)
E-mail: haseena@bangla.net
Back
to top
Education
1978 B.Sc. Honors in Biochemistry. Obtained First Class. Department
of Biochemistry, University of Dhaka, Dhaka, Bangladesh.
1980 M.Sc. in Biochemistry. Obtained First Class.
Department of Biochemistry, University of Dhaka, Dhaka, Bangladesh
1985 Doctorate of Philosophy, in Molecular Biology.
Nitrogen Fixation Laboratory, AFRC,
University of Sussex, Brighton, England.
Back
to top
Teaching Experience
01/82 - 09/82 Lecturer
Department of Biochemistry, University of Dhaka
10/82 - 01/87 On study leave.
02/87 - 03/90 Assistant Professor,
Department of Biochemistry, University of Dhaka
03/90 - 07/95 Associate Professor,
Department of Biochemistry, University of Dhaka
1995 - Professor,
Department of Biochemistry and Molecular Biology
University of Dhaka
Jan 2001- Chairperson
Department of Genetic Engineering and Biotechnology
University of Dhaka
Back
to top
Fellowships Obtained
1982 - 85 Ph.D. Fellowship Supported by a fellowship from the Association
of Commonwealth Universities
Project involved developing methods for site-directed mutation of
the nifLA promoter of Klebsiella pneumoniae such that single base-pair
changes would be made in order to determine by sequencing the mutated
promoter the specific nucleotides recognised by the transcriptional
activators, NifA and NtrC of the promoter.
1985–86 Post-doctoral
Research Fellow Laboratoire de Biologie Moléculaire, INRA-CNRS,
Castanet-Tolosan, France. Supported by Elf-BioRecherche
Project involved
construction of a genomic bank of the leguminous plant alfalfa (Medicago
sativa) to isolate and study the nodule specific plant genes formed
in the symbiotic relationship between Rhizobium meliloti and Medicago
sativa.
1991-92 Research Fellow Nitrogen Fixation Laboratory, University of
Sussex, Sussex, U.K. Fellowship provided by the British Council, U.K.
Project involved
cloning of the nif H gene of Klebsiella pneumoniae into the Ti plasmid
of Agrobacterium tumefaciens. Agrobacterium mediated transformation
of Nicotiana tabacum (tobacco) and screening of the transgenic plants
for the nif H gene were also part of the project which included extensive
plant tissue culture work.
1992–1995
Research Associate, (supported by a fellowship of the Medical Research
Council of Canada) Reproduction Research Laboratory Clinical Research
Institute of Montreal, Montreal, Quebec, Canada
Project involved characterization of alternatively spliced variants
of sheep testicular follicle stimulating hormone receptors by cloning
cDNA of the variants into eukaryotic expression vectors and studying
their expression in euckryotic cells. These clones had also been engineered
for prokaryotic expression. These proteins made in the bacteria have
been successfully purified and used in the production of antibodies
against them in the rabbits.
Back
to top
Award Obtained
1989 UNESCO/ROSTSCA Award for young scientist in the field of Biotechnology
Educational Affiliation
Membership
1. President, Graduate Biochemists Association,
GBA
2. Member, Bangladesh Biochemical Society
4. Member, Editorial Board “Bangladesh Journal of Biochemistry”
3. Member, Editorial Board "Dhaka University Journal of Biological
Sciences"
Organizer
International Hands-on Training Workshop on “Novel DNA Markers
for Crop Improvement ” Sponsored by ICGEB and Departments of
Botany and
Biochemistry and Molecular Biology, University of Dhaka, Bangladesh
Nov. 4-13 2001.
Back
to top
Principal Investigator of Research Projects
a. Research Grant (2001-2004) from the US Department of Agriculture,
amounting to US $ 250,000 for “ Genetic Improvement by Marker-Aided
Selection and Transformation”
b. Research Grant
(1999-2000) “Upgrading of Laboratory Facilities for Conversion
to Molecular Biology Laboratory Suitable for DNA Fingerprinting for
Practical Applications”. Funding by the Ministry of Science and
Technology, Gov., of the Peoples Republic of Bangladesh. Amount Funded
Taka 30,00,000.
c. Research Grant
(1998-1999) DNA Fingerprinting: an aid for Plant Breeders. Funding
by the Ministry of Science and Technology, Gov., of the Peoples Republic
of Bangladesh. Amount Funded Taka 6,50,000.
Back
to top
Scientific Publications and Communication
1. Effect of different growth substrates on the regulation of the
enzymes of the glyoxylate cycle in Pseudomonas aeruginosa. Effect
of different growth substrates on the regulation of the enzymes of
the glyoxylate cycle in Pseudomonas aeruginosa strains.
Rahman, M. and BANU, H. Journal of the Bangladesh Academy of Sciences,
6.#1&2, 1982.
2. Site-directed
mutagenesis of the Klebsiella pneumonia nifL and nifH promoter activity.
Martin Buck, Haseena KHAN and Ray Dixon. 1985. Nucleic Acids Research
13, 7621-7633.
3. nif promoter
structure in Klebsiella pneumonia.
Martin Buck, Stephen Miller, Haseena KHAN, Martin Drummond and Ray
Dixon. 1985. Nitrogen Fixation Research Progress. H.J. Evans, P.J.
Bottomley and W.E. Newton (eds).
4. Deletion loop mutagenesis of the nifL promoter from Klebsiella
pneumonia: role of the -26 to -12 region in promoter function.
Haseena KHAN, Martin Drummond and Ray Dixon. 1986. Gene 45, 281-288.
5. Regulation
of the nitrogen fixing genes in Klebsiella pneumonia: Implications
for genetic manipulation.
R.A. Dixon, M. Buck, M. Drummond, T. Hawkes, H. KHAN, S. MacFarlane,
M. Merrick and J.R. Postgate. 1986. Plant and Soil. 90, 225-233.
6. Identification
of two groups of leghemoglobin genes in alfalfa and a study of their
expression during root nodule development.
David Barker, Phillip Gallusci, Valerie Lullien, Haseena KHAN, Michelle
Gherardi and Thierry Huguet. 1988. Plant Molecular Biology 11, 761.
7. Host-controlled restriction and modification of phage SK101 and
its mutants by different Shigella species.
Mustafizur Rahman, Hossain Uddin Shekhar and Haseena KHAN. 1992. Dhaka
Univ. J. Biol. Sci. 1(1), 65-70.
8. Cloning of
alternately spliced mRNA transcripts coding for variants of ovine
testicular follitropin receptor lacking the G protein coupling domains.
Haseena KHAN, T.A. Yarney, and M.R. Sairam. 1993. Biochem. Biophys.
Res. Commun. 190, 888-894.
9. Molecular cloning
and expression of the ovine testicular follicle stimulating hormone
receptor. T.A. Yarney, M.R. Sairam, H. KHAN, N. Ravindranath, S. Payne
and N.G. Seidah. 1993. Molecular and Cellular Endocrinology 93, 219-226.
Back
to top
10. Follitropin Signal Transduction : Alternative Splicing of the
FSH Receptor Gene Produces a Dominant Negative Form of Receptor Which
Inhibits Hormone Action.
M.R.Sairam, L.G.Jiang,T.A.Yarney and H. Khan. 1996
Biochem. Biophys. Res. Commun. 226, 717-722
11. Ontogeny of FSH receptor messenger ribonucleic acid transcripts
in relation to FSH
secretion and testicular function in sheep.
T.A. Yarney, M.H. Fahmy, M.R. Sairam, H. Khan and E.A. MacDonald.
1997.
J. Mol. Endorinol. 18(2), 113-125.
12. Recognition
of follicle stimulating hormone (alpha-subunit) by a recombinant receptor
protein domain coded by an alternately spliced mRNA and expressed
in Escherichia coli.
H. Khan, L.G. Jiang, G.N. Jayashree, T.A. Yarney and M.R. Sairam.
1997.
J. Mol. Endocrinol. 19(2), 183-190.
13. Alternative
splicing converts the G-protein coupled follitropin receptor gene
into a growth factor type I receptor: implications for pleitropic
actions of the hormone.
M.R. Sairam L.G. Jiang T.A. Yarney and H. Khan. 1997.
Mol. Repro. Dev. 48(4), 471-479.
Back
to top
14. Molecular
cloning, structure and expression of a testicular follitropin receptor
with selective alteration in the carboxy terminus that affects signalling
function.
T.A. Yarney, L. Jiang, H. Khan, E.A. MacDonald, D.W. Laird and M.R.
Sairam. 1997.
Mol. Reprod. Dev. 48(4) 458-470.
15. Immunization
of male bonnet monkeys(M. radiata) with a recombinant FSH receptor
preparation affects testicular function and fertility.
N.R. Moudgal, M.R. Sairam, H.N. Krishnamurty, S. Sridhar H. Krishnamurty
and H. Khan. 1997. Endocrinology 138, 3065-3068.
16. Transformation
of jute (Corchorus capsularis L. vars CVL-1 and D-154) with the plasmids
pCAMBIA 1201,pBI 121 and pBINCHI 11 and high efficiency marker gene
insertion in explants.
M.B. Hossain, M.H. Khan, E.H. Chowdhury, F.T. Zohra, Z.I. Seraj, H.
Khan and R.H. Sarker. 1999. Proceedings of the Workshop on Application
of Biotechnology in the Improvement of Jute, Kenaf and Allied Fibres-Phase
II (IJO/AGRI/10).
17. Potential Improvement of Jute by Biotechnological Approaches.
H. Khan, Z.I. Seraj, R.H. Sarker, L.Khandekar, S. Begum, N. Hossain,
K.M. Ali, M. B. Hossain, F.T. Zohra, S. Haque and S. Hossain. 2000.
Proceedings of the Final Workshop on Application of Biotechnology
in the Improvement of Jute, Kenaf and Allied Fibres-Phase II (IJO/AGR/10).
18. M. Morshed,
H. Khan and S. Akhteruzzaman (2000). Association between Angiotensin-I
Converting Enzyme (ACE) gene polymorphism and hypertension in a Bangladeshi
population. Journal of Biochemistry and Molecular Biology (In Press)
Back
to top
Scientific Presentations
1. In-vitro mutagenesis of two nif promoters of Klebsiella pneumonia.
M. Buck, J.Clements, H. KHAN and R. Dixon. Oligonucléotides
et Génétique Moléculaire, Aussois, France. January
8-12, 1985.
2. Plant gene
expression in effective and ineffective nodules of Medicago Sativa.
Valerie Lullien, Michelle Gherardi, David Barker, Haseena KHAN, Marie-Noëlle
de Solan, Phillip de Lajudie and Thierry Huguet. Third International
Symposium on Molecular Genetics of Plant-Microbes Interactions. Montreal,
Canada. July 27-31,1986.
3. Alternative
splicing: A common phenomenon for ovine FSH receptor gene regulation
Haseena KHAN, T.A.Yarney, M.R.Sairam. 36th Annual Meeting, Canadian
Federation of Biological Societies. Windsor, Canada. June 17-19, 1993.
4. Bacterial synthesis
and characterization of the N?terminus half of the extracellular hormone
binding domain of the ovine follitropin receptor.
H. KHAN, L.G. Jiang, G.N. Jayashree, T.A. Yarney and M.R.Sairam. 10-minute
paper, 37th Annual Meeting, Canadian Federation of Biological Societies.
Montreal, Canada. June 1994.
5. Functional
expression of the recombinant FSH receptor isoform bearing a modified
cytoplasmic domain.
L.G. Jiang, T.A. Yarney, D.W. Laird, H. KHAN, and M.R.Sairam. Second
Annual Research Day for the Montreal Area Reproductive and Developmental
Biologists. Montreal, Canada. November 1994.
6. Potential Improvement
of Jute by Biotechnological Approaches.
Final Workshop on Application of Biotechnology in the Improvement
of Jute, Kenaf
and Allied Fibres-Phase II. H. Khan, Z.I. Seraj, R.H. Sarker, L.Khandekar,
S. Begum, N. Hossain, K.M. Ali, M. B. Hossain, F.T. Zohra, S. Haque
and S. Hossain. 2000.
Beijing, China from July 8-12, 2000.
7. DNA Fingerprinting of Commercial and Flood Tolerant Jute by RAPD.
Haseena Khan, Nazir Hossain, K. Mohammed Ali, Samiul Haque, Rakhari
Hari Sarker, Selina Begum, Zeba I. Seraj and Shamim Hossain. Invited
Speaker at the Tenth Asian Symposium on Medicinal Plants, Spices and
Other Natural Products (ASOMPS X). 18-23 November 2000, Dhaka, Bangladesh
Back
to top
|
